Defined extracellular matrix components are necessary for definitive endoderm induction
نویسندگان
چکیده
منابع مشابه
Traction forces mediated by integrin signaling are necessary for definitive endoderm specification.
Pluripotent embryonic stem cells (ESCs) exert low-traction forces on their niche in vitro whereas specification to definitive endoderm in vivo coincides with force-mediated motility, suggesting a differentiation-mediated switch. However, the onset of contractility and extent to which force-mediated integrin signaling regulates fate choices is not understood. To address the requirement of tracti...
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ژورنال
عنوان ژورنال: STEM CELLS
سال: 2013
ISSN: 1066-5099
DOI: 10.1002/stem.1453